Jesse W. Karr

Associate Professor of Chemistry and Biochemistry

Phone: (518) 782‑6716
Email: jkarr@siena.edu

Jesse W. Karr

Degrees:

Ph.D. Chemistry University of Maryland, Baltimore County
B.S. Chemistry State University of New York College at Plattsburgh

Bio:


After receiving a bachelors degree in chemistry (with a minor in environmental science) from the State University of New York at Plattsburgh, I attended the University of Maryland, Baltimore County where I worked with Veronika Szalai characterizing the Cu(II) binding site of the Amyloid-β (Aβ) peptide of Alzheimer’s Disease. Before moving to Siena, I was a Post-Doctoral Faculty Fellow at Boston University where I supported both their General Chemistry and Inorganic Chemistry courses. While at BU I worked with John Caradonna to characterize the non-heme iron center of Phenylalanine Hydroxylase (PAH), an enzyme which has been linked to Phenylketonuria (PKU).

What I love about Siena:

I like teaching at Siena because of the sense of community its faculty tries and foster for their students. Being able to get to know my students takes them from being just “a line in a grade book” to young scholars. This also allows me the opportunity to watch them grow and develop throughout their academic careers, which I truly appreciate as an educator.

My Favorite courses to teach are:

  • General Chemistry
  • Inorganic Chemistry
  • Physical Biochemistry
  • Biochemical Mechanics
  • Advanced Biochemical Methods

Professional Experience:

Associate Professor of Chemistry and Biochemistry Siena College 2016 - Now
Assistant Professor, Chemistry and Biochemistry Siena College 2010 - 2016
Postdoctoral Faculty Fellow Boston University 2008 - 2010

Office Hours:

MON: 04:00 PM-05:30 PM
TUE:
WED: 09:00 AM-11:30 AM
THU: 04:30 PM-05:30 PM
FRI:

My current research:


My research pursuit has always been to better understand the roles of metal ions in biological systems; more specifically the way some metal ions act as toxins and how they cause various diseases. Currently, my research projects center on elucidating the affect(s) Pb(II) has on different biological systems and determine the ways this metal ion is responsible for the symptoms exhibited by a person afflicted with lead poisoning.

My teaching philosophy:

"In education it isn’t how much you have committed to memory…. It’s being able to differentiate between what you do know and what you don’t. It’s knowing where to go to find out what you need to know and it’s knowing how to use the information you get." William Feather


Synthesis and Characterization of Thermochromic Metal Compounds With a Near Room Temperature High-Spin to Low-Spin Crossover
Chemical Educator, vol. 20
2015
Local Structure and Global Patterning of Cu2+ Binding in Fibrillar Amyloid-? [A?(1–40)] Protein
Journal of the American Chemical Society, vol. 134
2012
Cu(II) Binding to Monomeric, Oligomeric, and Fibrillar Forms of the Alzheimer's Disease Amyloid-? Peptide
Biochemistry, vol. 47
2008
Role of Aspartate-1 in Cu(II) Binding to the Amyloid-? Peptide of Alzheimer's Disease
Journal of the American Chemical Society, vol. 129
2007
N-Terminal Deletions Modify the Cu2+ Binding Site in Amyloid-?
Biochemistry, vol. 44
2005
Amyloid-? Binds Cu2+ in a Mononuclear Metal Ion Binding Site
Journal of the American Chemical Society, vol. 126
2004
McGraw-Hill Yearbook of Science and Technology, 2010
McGraw-Hill Professional
ISBN: 978-026262077
2010
Writing research proposals across the undergraduate curriculum: Adapting a VIPEr Learning Object for use in multiple courses
2016
251st American Chemical Society National Meeting & Exposition, San Diego, California
Probing the structural difference between Ca(II) and Pb(II) bound syt1
2016
251st American Chemical Society National Meeting & Exposition, San Diego, California
Writing Research Proposals Across the Undergraduate Curriculum: Adapting a VIPEr Learning Object For Use in Multiple Courses
2016
2016 Biennial Conference on Chemical Education, Greeley, Colorado
Synthesis and Characterization of Thermochromic Metal Complexes With Near Room Temperature Spin Crossover: An undergraduate laboratory experiment
2016
2016 Biennial Conference on Chemical Education, Greeley, Colorado
An Advanced Biochemistry Laboratory Experience Independent of Discipline
2016
2016 Biennial Conference on Chemical Education, Greeley, Colorado
Tourism and Revitalization in the Arbor Hill Neighborhood of Albany
2016
Siena Summer Research Symposium, Loudonville, New York
Developing a Thermodynamic Ruler for Predicting Protein Unfolding
2016
Siena Summer Research Symposium, Loudonville, New York
Probing the Structural Difference Between Ca(II) and Pb(II) Bound Syt1
2016
Siena Summer Research Symposium, Loudonville, New York
Probing the Metal Induced Association Between Synaptotagmin-1 and Syntaxin-1A
2015
Siena College Summer Research Symposium, Loudonville, New York
Investigation of the Metal-Binding Properties of Synaptotagmin-1
2015
7th Annual Eastern New York American Chemical Society Undergraduate Research Symposium, Loudonville, New York
Spectrophotometric and Calorimetric Characterization of Syt1 in the Presence of Ca(II) and Pb(II)
2014
6th Annual Eastern New York American Chemical Society Undergraduate Research Symposium, Loudonville, New York
Synthesis and Characterization of Thermochromic Metal Complexes with a Near Room Temperature Spin Crossover
2014
6th Annual Eastern New York American Chemical Society Undergraduate Research Symposium, Loudonville, New York
Preparing PUI Students for Critical Thinking, Writing, and Presentation Skills Applicable to Graduate School
2014
2014 Biennial Conference on Chemical Education, Allendale, Michigan
Redesigning the General Chemistry Laboratory Curriculum to an Atoms-first Approach
2014
2014 Biennial Conference on Chemical Education, Allendale, Michigan
The Effect of Pb2+ on the Association Between Membrane Bound Synaptotagmin-1 and Syntaxin 1A
2014
Siena Summer Research Symposium, Loudonville, New York
Characterization of the Metal-induced Interaction of Syntaxin-1A and Synaptotagmin-1
2013
5th Annual Eastern New York American Chemical Society Undergraduate Research Symposium, Loudonville, New York
Characterization of Pb2+-bound Synaptotagmin-1
2013
5th Annual Eastern New York American Chemical Society Undergraduate Research Symposium, Loudonville, New York
Synthesis and Characterization of Thermochromic Metal Compounds With Room Temperature 5T2g -> 1A1g Crossovers
2013
5th Annual Eastern New York American Chemical Society Undergraduate Research Symposium, Loudonville, New York
Synaptotagmin Purification and Metal-Induced Changes
2013
Siena Summer Research Symposium, Loudonville, New York
Characterization of the Pb(II) Coordination Environment in Synaptotagmin-1
2013
Siena Summer Research Symposium, Loudonville, New York
Optimization of the Overexpression and Purification of the Aminolevulinic Acid Dehydratase Enzyme
2012
4th Annual Eastern New York American Chemical Society Undergraduate Research Symposium, Loudonville, New York
Characterization of Pb2+ Bound Synaptotagmin 2
2012
243rd American Chemical Society National Meeting & Exposition, San Diego, California
Characterization of Pb2+ Bound Synaptotagmin 1
2012
4th Annual Eastern New York American Chemical Society Undergraduate Research Symposium, Loudonville, New York
Characterization of the Quaternary Structure of Synaptotagmin-1
2012
Siena Summer Research Symposium, Loudonville, New York
Characterization of Pb2+-bound Synaptotagmin-1
2012
Siena Summer Research Symposium, Loudonville, New York